A quantitative comparison of the influence of individual versus population-derived vascular input functions on dynamic contrast enhanced-MRI in small animals

作者：Loveless Mary E; Halliday Jane; Liess Carsten; Xu Lei; Dortch Richard D; Whisenant Jennifer; Waterton John C; Gore John C; Yankeelov Thomas E^*

来源：Magnetic Resonance in Medicine, 2012, 67(1): 226-236.

DOI：10.1002/mrm.22988

• DCE-MRI
• vascular input function
• tumor
• pharmacokinetics
• mice

For quantitative analysis of dynamic contrast enhanced magnetic resonance imaging data, the time course of the concentration of the contrast agent in the blood plasma, or vascular input VIF), is required. We compared pharmacokinetic parameters derived using individual and population-based VIFs in mice for two different contrast agents, gadopentetate dimeglumine and P846. Eleven mice with subcutaneous 4T1 breast cancer xenografts were imaged at 7 T. A precontrast T1 map was acquired along with dynamic T1-weighted gradient echo images before, during, and after a bolus injection of contrast agent delivered via a syringe pump. Each animal's individual VIF and derived population-averaged VIF were used to extract parameters from the signal-time curves of tumor tissue at both the region of interest and voxel level. The results indicate that for both contrast agents, Ktrans values estimated using population-averaged VIF have a high correlation (concordance correlation coefficient > 0.85) with Ktrans values estimated using individual VIF on both a region of interest and voxel level. This work supports the validity of using of a population-based VIF with a stringent injection protocol in preclinical dynamic contrast enhanced magnetic resonance imaging studies. Magn Reson Med, 2011.

• 出版日期2012-1