Glasgow prognostic score after concurrent chemoradiotherapy is a prognostic factor in advanced head and neck cancer

作者：Chang Pei Hung^*; Wang Cheng Hsu; Chen Eric Yen Chao; Yang Shih Wei; Chou Wen Chi; Hsieh Jason Chia Hsun; Kuan Feng Che; Yeh Kun Yun

来源：Chinese Journal of Cancer Research, 2017, 29(3): 172-178.

DOI：10.21147/j.issn.1000-9604.2017.03.02

• Glasgow prognostic score (GPS)
• head and neck cancer
• chemoradiation
• inflammation
• cachexia
• nutrition

Objective: This study aims to evaluate the impact and potential prognostic roles of the pre- and post-treatment Glasgow prognostic score (GPS) and the change thereof in patients with advanced head and neck cancer undergoing concurrent chemoradiotherapy (CCRT).
Methods: We collected GPS and clinicopathological data of 139 stage III, IVA, and IVB head and neck cancer patients who underwent CCRT between 2008 and 2011. Their GPSs pre- and post-CCRT and the change thereof were analyzed for correlations with recurrence and survival.
Results: The GPS changed in 72 (51.8%) patients, with worse scores observed post-CCRT in 65 (90.3%) of the GPS changed patients. Patients in the improved GPS group showed a tendency toward better survival. From the multivariate analysis, the post-CCRT GPS level was an independent prognostic factor in addition to tumor stage.
Conclusions: After CCRT, a high GPS was revealed to be an important predictor of survival for advanced head and neck cancer.

• 出版日期2017-6
• 单位长春大学