Sp1 and COX2 expression is positively correlated with a poor prognosis in pancreatic ductal adenocarcinoma

作者：Hang, Junjie; Hu, Hai; Huang, Junjie; Han, Ting; Zhuo, Meng; Zhou, Yangyang; Wang, Lei; Wang, Yi; Jiao, Feng^*; Wang, Liwei

来源：Oncotarget, 2016, 7(19): 28207-28217.

DOI：10.18632/oncotarget.8593

• pancreatic ductal adenocarcinoma
• specificity protein 1
• cyclooxygenase-2
• correlation
• prognosis

Previous studies showed that celecoxib, a cyclooxygenase-2 (COX2) inhibitor, can inhibit angiogenesis and metastasis of pancreatic ductal adenocarcinoma (PDAC) via the suppression of specificity protein 1 (Sp1). In this study, we investigated the prognostic value of Sp1 and COX2 in 88 PDAC patients. Our study showed there was a positive correlation between Sp1 and COX2 expression (P=0.001) by using the Spearman's rank test. Pearson Chi-square test revealed that Sp1 and COX2 expression were positively associated with lymph node metastasis (P<0.05, both). In addition, the Kaplan-Meier analysis showed that patients with Sp1- or COX2-positive expression exhibited poorer overall survival (OS) than those with Sp1- or COX2-negative expression (P<0.05, all). Most importantly, Sp1- and COX2-negative patients had the best OS (P=0.01). In multivariate analysis, Sp1 expression (P=0.03), COX2 expression (P=0.04), and nuclear grade (P=0.009) were found to be independent predictors for OS. Moreover, we confirmed that Sp1 could upregulate the expression of COX2 in PDAC cell lines by western blot analysis, and both are of important prognostic value in PDAC.

• 出版日期2016-5-10
• 单位深圳大学; 蚌埠医学院; 上海交通大学