Membrane and Soluble ILT3 Are Critical to the Generation of T Suppressor Cells and Induction of Immunological Tolerance

作者：Vlad George; Chang Chih Chao; Colovai Adriana I; Vasilescu Elena R; Cortesini Raffaello; Suciu Foca Nicole^*

来源：International Reviews of Immunology, 2010, 29(2): 119-132.

DOI：10.3109/08830180903281185

• tolerance
• dendritic cells
• ILT receptors
• T suppressor cells

The tolerogenic phenotype of human dendritic cells is characterized by high cell surface expression of the inhibitory receptor ILT3. ILT3 signals both intracellularly inhibiting tyrosine phosphorylation, NF-kappa B and MAPK p38 activity, transcription of certain co-stimulatory molecules, secretion of cytokines and chemokines, and extracellularly into the T cells with which the dendritic cells interact. Both ILT3(high) tolerogenic dendritic cells and soluble ILT3 induce CD4 Th anergy and differentiation of antigen specific CD8 T suppressor cells. Recombinant ILT3-Fc protein has important immunotherapeutic potential acting directly on activated T cells and promoting the induction of immunological tolerance.

• 出版日期2010-4