Association between single nucleotide polymorphisms of the transforming growth factor-beta1 gene and overall survival in unresectable locally advanced non-small-cell lung cancer patients treated with radio(chemo)therapy in a Chinese population

作者：Xue Sheng Liu; Zheng Yi Hu; Su Hua Fang; Deng Xia; Zhang Xue Bang; Zou Chang Lin; Hu Mei Long; Xie Cong Ying^*

来源：Medical Oncology, 2013, 30(2): 512-512.

DOI：10.1007/s12032-013-0512-0

• Non-small-cell lung cancer
• Survival
• Transforming growth factor-beta1
• Single-nucleotide polymorphism

The outcome is variable for unresectable locally advanced non-small-cell lung cancer (ULANSCLC) patients treated with radio(chemo) therapy. The aim of this study is to investigate whether single-nucleotide polymorphisms (SNPs) in the transforming growth factor-beta1 (TGF-beta 1) gene are associated with overall survival (OS) in ULANSCLC patients treated with definitive radio(chemo) therapy. A total of 109 patients who had available blood samples and complete clinical and follow-up information were enrolled. DNA from blood was genotyped for two SNPs: TGF-beta 1 C-509T and T+869C. Kaplan-Meier survival analysis, log-rank test, and Cox's proportional hazard model were used to evaluate associations between genotypes and OS. Log-rank test showed that TGF-beta 1 C-509T significantly correlated with OS (pooled P = 0.017). Both univariate and multivariate analyses showed that TGF-beta 1 C-509T CC genotype was significantly associated with better OS than CT or TT genotypes. These results indicate that TGF-beta 1 C-509T CC genotype is significantly associated with better OS in ULANSCLC patients treated with radio(chemo) therapy as a potential independent survival predictor.

• 出版日期2013-6
• 单位温州医科大学