Association of MTHFR 6771 variant allele with risk of intracerebral haemorrhage: A meta-analysis

作者：Gao, Shan; Li, Hongzhao; Xiao, Haijun^*; Yao, Guoxiang; Shi, Yihai; Wang, Yongli; Zhou, Xingsheng; Yu, Haifu

来源：Journal of the Neurological Sciences, 2012, 323(1-2): 40-45.

DOI：10.1016/j.jns.2012.07.038

• Methylenetetrahydrofolate reductase
• Intracerebral haemorrhage
• Polymorphism
• Meta-analysis

Background: Previous studies concerning the association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and risk of intracerebral haemorrhage (ICH) reported conflicting results. A meta-analysis of published studies was performed to allow a more reliable estimate of this association.
Methods: Relevant studies concerning the association between MTHFR C677T polymorphism and risk of ICH were included into this meta-analysis. Odds ratios (OR) and 95% confidence intervals (Cl) were determined for this gene-disease association using fixed or random effect models.
Results: Finally, 16 studies with a total of 1828 cases and 4067 controls were included. Meta-analyses of a total of 16 studies showed that there was an obvious association of MTHFR 677T allele with risk of ICH under all four comparison models (ORT vs. C=1.38, 95% CI 1.17-1.62, P<0.001: ORTT vs. CC=1.90 95% CI 1.42-2.55, P<0.001: ORTT vs. TC/CC=138 95% CI 120-1.59, P<0.001; ORTT/TC vs. CC=1.41 95% CI 1.12-1.78, P=0.003). Besides, both subgroup analyses and sensitivity analysis further identified the association above.
Conclusion: The MTHFR 677T allele is associated with risk of ICH, and individuals with IT genotype have an obviously higher risk of ICH than those with the CC genotype.

• 出版日期2012-12-15
• 单位天津医科大学; 安徽科技学院; 上海交通大学