Neuropathy in a rat model of mild diabetes induced by multiple low doses of streptozotocin: effects of the antioxidant stobadine in comparison with a high-dose alpha-lipoic acid treatment

作者:Skalska Silvia*; Kucera Pavol; Goldenberg Zoltan; Stefek Milan; Kyselova Zuzana; Jariabka Pavol; Gajdosikova Alena; Klobucnikova Katarina; Traubner Pavel; Stolc Svorad
来源:General Physiology and Biophysics, 2010, 29(1): 50-58.
DOI:10.4149/gpb_2010_01_50

摘要

Hyperglycaemia-induced oxidative stress makes an important contribution to the aetiology of diabetic neuropathy. The aim of our study was to evaluate the effect of the antioxidant stobadine (STB) in comparison with a treatment by a high-dose of a-lipoic acid (ALA), on the neurological consequences of chronic hyperglycaemia in an animal model of diabetes in Wistar rats (16 weeks old), made diabetic by streptozotocin (STZ 3 x 20 mg i.v.).
Neuropathy was evaluated electrophysiologically by measuring motor nerve conduction velocity (NCV) in the 4(th) and 8(th) week in vivo and motor NCV and resistance to ischaemic conduction failure (RICF) of the sciatic nerve in the 10(th) week of the experiment in vitro. The therapy with ALA (100 mg/kg i.p., 5 times a week) and STB (25 mg/kg i.p., 5 times a week) had a significant effect on NCV in vivo in the 8th week of the experiment and no effect in the 10th week in vitro. The RICF elevated in diabetic animals was significantly modified by ALA. The effect of the antioxidant STB on NCV was comparable with that of ALA, while RICF was affected only by ALA.
We conclude that treatment with appropriate antioxidants might partially prevent nerve dysfunction in diabetic rats.

  • 出版日期2010-3