科研之友
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摘要
Two phloroglucinols named tomentosones A and B (1 and 2) that each possess a novel hexacyclic ring system were isolated from the CH2Cl2 extract of Rhodomyrtus tomentosa leaves. Their structures were elucidated from analyses of 2D NMR spectroscopic data. Tomentosone A inhibited the growth of chloroquine-resistant and -sensitive strains of the malaria parasite Plasmodium falciparum, with IC50 values of 1.49 mu M and 1.0 mu M, respectively, while tomentosone B was significantly less active.
- 出版日期2012-1-6
