mTHPC mediated interstitial photodynamic therapy of recurrent nonmetastatic base of tongue cancers: Development of a new method

作者：Karakullukcu Baris^*; Nyst Heike J; van Veen Robert L; Hoebers Frank J P; Hamming Vrieze Olga; Witjes Max J H; de Visscher Sebastiaan A H J; Burlage Fred R; Levendag Peter C; Sterenborg Henricus J C M; Tan I Bing

来源：Head and Neck-Journal for the Sciences and Specialties of the Head and Neck, 2012, 34(11): 1597-1606.

DOI：10.1002/hed.21969

• photodynamic therapy
• base of tongue cancer
• recurrence
• brachytherapy
• palliative therapy
• head and neck

Background Interstitial photodynamic therapy (iPDT) can be an option in the management of locally recurrent base of tongue cancer after (chemo)radiation treatment. The purpose of the current study was to develop a technique to implant light sources into the tumor tissue. Methods Twenty patients with previously irradiated locally recurrent base of tongue cancers who were not candidates for salvage surgery or reirradiation or refused these therapies were included in this study. The treatment planning was done on MRI. The light sources were implanted using modified brachytherapy techniques. Results The iPDT could be conducted in all patients without short-term complications. At 6 months, 9 patients had complete response with 4 patients still free of disease (4680 months). Long-term complications included pharyngocutaneous fistula in 6 patients, serious bleeding in 1 patient, and cutaneous metastasis in 2 patients. Conclusion The initial results are encouraging. There is room for improvement to control the destructive potential of iPDT through planning and monitoring tools.

• 出版日期2012-11