A smaller endotracheal tube combined with intravenous lidocaine decreases post-operative sore throat - a randomized controlled trial

作者：Xu Y J; Wang S L; Ren Y; Zhu Y; Tan Z M^*

来源：Acta Anaesthesiologica Scandinavica, 2012, 56(10): 1314-1320.

DOI：10.1111/j.1399-6576.2012.02768.x

Background Post-operative sore throat (POST) has increasingly been a common clinical complication particularly in thyroid surgery. We conducted a trial to evaluate the effect of non-pharmacological [smaller-sized endotracheal tube (ETT)] combined with pharmacological intervention [lidocaine intravenous (i.v.)] on POST in women undergoing thyroid surgery. Methods Two hundred and forty patients scheduled for thyroid surgery were randomly divided into four groups: Group A, ETT size 7.0 with saline; Group B, ETT size 6.0 with saline; Group C, ETT size 7.0 with lidocaine; Group D, ETT size 6.0 with lidocaine. Patients in Groups C and D received i.v. 1.5?mg/kg lidocaine that was filled in syringe up to 10?ml 5?min before induction of anaesthesia; whereas patients in Groups A and B received an equal volume of saline. The incidence and severity of POST were evaluated at 1, 6 and 24?h after tracheal extubation. Results The highest incidence of POST occurred at 6?h after extubation in all groups. The incidence of POST was significantly lower in Group D compared with Groups A (23% vs. 62%, P?<?0.01), B (23% vs. 42%, P?=?0.03) and C (23% vs. 43%, P?=?0.02) at 6?h after extubation. Group D had significantly decreased severity of POST compared with Groups A, B and C 6 and 24?h after extubation (P?<?0.05). Conclusion Use of smaller-sized ETT combined with i.v. lidocaine decreases the incidence and severity of POST in women undergoing thyroid surgery.

• 出版日期2012-11
• 单位复旦大学