Anti-inflammatory cembranolides from the soft coral Lobophytum durum

作者：Cheng, Shi Yie; Wen, Zhi Hong; Wang, Shang Kwei; Chiou, Shu Fen; Hsu, Chi Hsin; Dai, Chang Feng; Duh, Chang Yih^*

来源：Bioorganic & Medicinal Chemistry, 2009, 17(11): 3763-3769.

DOI：10.1016/j.bmc.2009.04.053

• Lobophytum durum
• Cembranolides
• Antibacterial activities
• Anti-inflammatory effects
• HCMV endonuclease activity

Chemical investigation of the soft coral Lobophytum durum resulted in the isolation of seven new cembranolides, durumolides F-L (1-7), as well as one previously characterized cembranolides, sinularolide D (8). The molecular structures of these isolated metabolites were determined mainly through NMR techniques and HRESIMS analysis. Moreover, the absolute configurations of 1 and 5 were established by application of modified Mosher's method. The antibacterial activities, anti-inflammatory effects, and anti-HCMV (Human cytomegalovirus) endonuclease activity of metabolites 1-8 were also evaluated in vitro. Anti-inflammatory activity of metabolites 1 and 6 (10 mu M) significantly reduced the levels of the iNOS protein to 0.8 +/- 0.6% and 5.7 +/- 2.2%, respectively, and COX-2 protein to 47.8 +/- 9.0% and 71.6 +/- 5.8%, respectively. Metabolites 1-8 (100 mu g/disk) exhibited weak antibacterial activity against Salmonella enteritidis.

• 出版日期2009-6-1
• 单位中山大学