A versatile nanoarray electrode produced from block copolymer thin films for specific detection of proteins

作者：Fayad Samira J; Minatti Edson; Soldi Valdir; Fort Sebastien; Labbe Pierre; Borsali Redouane^*

来源：Polymer, 2017, 123: 128-136.

DOI：10.1016/j.polymer.2017.07.015

• Self-assembly
• Thin film
• Single molecule
• Block copolymer
• Nanoelectrode arrays
• Cyclodextrin
• Electrochemistry

This work describes how nanostructured thin films obtained from the self-assembly of block copolymers (BCPs) systems can be used as a nanoelectrode array (NEA) that can be programmed to specifically detect targeted molecules. Namely, poly(styrene-b-methacrylate) (PS-b-PMMA) thin films, after removal of PMMA phase, produced regular spaced 560 pores mu m-2 with 16 nm of diameter. The nanopores were then chemically modified by the introduction of b-cyclodextrin (beta-CD) molecules. By using the supra-molecular interaction of beta-CD and ferrocene (Fc), the pores could be programed by the introduction of molecules linked to Fc able to interact with target species. In the model system shown here, the linker had a biotin unit, aiming the detection of streptavidin. By changing the linker, other molecules can also be detected. This concept opens a window to many possibilities, including the development of devices for fast and versatile molecule detection.

• 出版日期2017-8-11