Auditory event-related potentials at preschool age in children born very preterm

作者：Hovel Holger^*; Partanen Eino; Huotilainen Minna; Lindgren Magnus; Rosen Ingmar; Fellman Vineta

来源：Clinical Neurophysiology, 2014, 125(3): 449-456.

DOI：10.1016/j.clinph.2013.07.026

• Very premature infant
• Event-related potential (ERP)
• Mismatch negativity (MMN)
• N1
• P2
• Maturation
• Cognitive disorders

Objective: To assess auditory event-related potentials at preschool age in children born very preterm (VP, 27.4 +/- 1.9 gestational weeks, n = 70) with a high risk of cognitive dysfunction. %26lt;br%26gt;Methods: We used an oddball paradigm consisting of a standard tone randomly replaced by one of three infrequent deviants (differing in frequency, sound direction or duration). %26lt;br%26gt;Results: The P1 and N2 latencies were inversely correlated to age (50-63 months) both in VP (r = -0.451, p %26lt; 0.001, and r = -0.305, p = 0.01, respectively) and term born controls (TC; n = 15). VP children had smaller P1 than near-term (n = 12) or TC (1.70 +/- 0.17 mu V vs 2.68 +/- 0.41 and 2.92 +/- 0.43, respectively; p %26lt; 0.05). Mismatch negativity response did not differ between groups. %26lt;br%26gt;Conclusions: Our data suggest a fast maturation of P1 and N2 responses with fast decrease in P1 and N2 latencies around the age of 5 years. Mismatch negativity response does not seem to be a robust measure for defining abnormalities in VP children. %26lt;br%26gt;Significance: In ERP studies in preschool children, even small, non-significant group differences in age at recording should be corrected for. Very preterm born children at preschool age have aERP patterns as earlier described in full-term born children with cognitive deficits.

• 出版日期2014-3