Determination of human absorbed dose of Tl-201(III)-DTPA-HIgG based on biodistribution data in rats

作者：Moghaddam Alireza Khorrami^*; Jalilian AmirReza; Hayati Vali; Shanehsazzadeh Saeed

来源：Radiation Protection Dosimetry, 2010, 141(3): 269-274.

DOI：10.1093/rpd/ncq172

To estimate the absorbed dose in normal organs and inflammated tissue following i.v. administration of [Tl-201](III)-DTPA-HIgG by using biodistribution data in inammation-bearing rats was attempted. The percentages of injected dose per gram of each organ were calculated. The medical internal radiation dose formulation was applied to calculate the absorbed dose for various organs. The inflammated tissue to blood activity concentration ratios were about 19 and 23.3 at 24 and 28 h post-injection, respectively. A 185-MBq injection of Tl-201-DTPA-HIgG into the human body, might result in an estimated absorbed dose of 14.4 mGy for the total body and the highest absorbed dose was in the kidney with 1195 (mGy) and second to the Spleen were the liver, the lungs and the adrenals, which received 250.5 (mGy), 58.64 (mGy) and 56.44 (mGy), respectively. Biodistribution of [Tl-201](III)-DTPA-HIgG demonstrated significant inflammated tissue uptake and low muscle and blood uptake, allowing for imaging of inflammated tissues.

• 出版日期2010-10