Stable IL-10: A New Therapeutic that Promotes Tumor Immunity

作者：Teng Michele W L; Darcy Phillip K^*; Smyth Mark J

来源：Cancer Cell, 2011, 20(6): 691-693.

DOI：10.1016/j.ccr.2011.11.020

In this issue of Cancer Cell, Mumm et al. demonstrate that pegylated IL-10 increases CD8(+) T cell numbers, IFN-gamma secretion, and cytotoxicity in established tumors, enhancing antigen presentation machinery and suppressing tumor growth. This approach may enhance T cell immune responses in cancers with reduced T cell infiltration.

• 出版日期2011-12-13