Animal models of tuberculosis

作者:Young Douglas*
来源:European Journal of Immunology, 2009, 39(8): 2011-2014.
DOI:10.1002/eji.200939542

摘要

There is a wide range of animal models of tuberculosis; which is fortunate, given that there is a wide range of complex biological phenomena to model. Nonetheless, the inadequacy of animal models is a chronic grievance amongst researchers, often expressed in the conclusion that the mouse is not a good model of human tuberculosis. There clearly are major differences between experimental infection of mice and natural infection of humans, but this overarching dogma is inconducive to fruitful research.