All-trans-retinoic Acid Promotes Iodine Uptake Via Up-regulating the Sodium Iodide Symporter in Medullary Thyroid Cancer Stem Cells

作者：Tang, Min; Hou, Yan-Li; Kang, Qiang-Qiang; Chen, Xing-Yue; Duan, Li-Qun; Shu, Jin; Li, Shao-Lin; Hu, Xiao-Li; Peng, Zhi-Ping^*

来源：Asian Pacific Journal of Cancer Prevention, 2014, 15(4): 1859-1862.

DOI：10.7314/APJCP.2014.15.4.1859

• ATRA
• medullary thyroid carcinoma stem cells
• the capability of radioiodine uptake
• I-131

Recently, the main therapy of medullary thyroid cancer (MTC) is surgical, but by which way there is a poor prognosis with a mean survival of only 5 years. In some cases, some researchers found that it is the medullary thyroid cancer stem cells (MTCSCs) that cause metastasis and recurrence. This study aimed to eradicate MTCSCs through administration of all-trans-retinoic acid (ATRA). Here we demonstrate that MTCSCs possess stem-like properties in serum-free medium. The ABCG2, OCT4 and sodium iodide symporter (NIS) were changed by ATRA. Additionally, we found that ATRA can increase the expression of NIS in vivo. All the data suggested that ATRA could increase the iodine uptake of MTCSCs through NIS.

• 出版日期2014
• 单位重庆医科大学