Anthropometric measures in middle age after exposure to famine during gestation: evidence from the Dutch famine

作者：Stein Aryeh D; Kahn Henry S; Rundle Andrew; Zybert Patricia A; an der Pal de Bruin Karin; Lumey L H^*

来源：American Journal of Clinical Nutrition, 2007, 85(3): 869-876.

DOI：10.1093/ajcn/85.3.869

• anthropometric measures
• body composition
• body mass index
• body size
• famine
• maternal and infant health
• Netherlands
• nutrition
• obesity

Background: Few studies in humans have related maternal undernutrition to the size of the adult offspring.
Objective: The objective was to assess whether reductions in food intake by pregnant women during the Dutch famine of 1944-1945 were related to offspring length, weight, and indexes of adiposity in middle age.
Design: We recruited 1) exposed persons born in western Netherlands between January 1945 and March 1946 whose mothers experienced famine during or immediately preceding pregnancy, 2) unexposed persons born in the same 3 institutions during 1943 or 1947 whose mothers did not experience famine during this pregnancy, and 3) unexposed same-sex siblings of persons in series 1 or 2. Anthropometric measurements (n = 427 males and 529 females) were obtained between 2003 and 2005. We defined 4 windows of gestational exposure (by ordinal weeks 1-10, 11-20, 21-30, and 31 through delivery) on the basis of exposure to a ration of < 900 kcal/d during the whole 10-wk interval.
Results: Exposure to reduced rations was associated with increased weight and greater indexes of fat deposition at several tissue sites in women but not in men (P for interaction < 0.01). Measures of length and linear proportion were not associated with exposure to famine.
Conclusion: Reduced food availability may lead to increased adiposity later in life in female offspring.

• 出版日期2007-3