Application of a 2-aryl indenylphosphine ligand in the Buchwald-Hartwig cross-coupling reactions of aryl and heteroaryl chlorides under the solvent-free and aqueous conditions

作者：Liu, Yan; Yuan, Jia; Wang, Zi-Fei; Zeng, Si-Hao; Gao, Meng-Yue; Ruan, Mei-Lin; Chen, Jian; Yu, Guang-Ao^*

来源：Organic and Biomolecular Chemistry, 2017, 15(27): 5805-5810.

DOI：10.1039/c7ob01199g

• PALLADIUM-CATALYZED AMINATION
• C-N
• PHOSPHINE-LIGANDS
• ORGANIC-REACTIONS
• ROOM-TEMPERATURE
• GREEN CHEMISTRY
• BOND FORMATION
• CARBON-CARBON
• WATER
• COMPLEXES

An efficient solvent-free protocol for the Buchwald-Hartwig cross-coupling reaction of aryl and heteroaryl chlorides with primary and secondary amines using the Pd(dba)(2)/ligand 1 catalytic system has been developed. Notably, the catalytic system also efficiently catalyzed the reaction under aqueous conditions.

• 出版日期2017-7-21
• 单位华中师范大学