Vitamin D-3 supplementation (4000 IU/d for 1 y) eliminates differences in circulating 25-hydroxyvitamin D between African American and white Men

作者：Garrett Mayer Elizabeth; Wagner Carol L; Hollis Bruce W; Kindy Mark S; Gattoni Celli Sebastiano^*

来源：American Journal of Clinical Nutrition, 2012, 96(2): 332-336.

DOI：10.3945/ajcn.112.034256

Background: African Americans suffer disproportionately from diabetes and cardiovascular disease and are significantly more likely to have suboptimal concentrations of circulating 25-hydroxyvitamin D [25(OH)D]. The results of epidemiologic and observational studies suggest that there is a link between vitamin D deficiency and the risk of cardiometabolic disorders, which underscores the importance of maintaining healthy concentrations of 25(OH)D. %26lt;br%26gt;Objective: The objective was to investigate whether daily supplementation with 4000 IU vitamin D-3 for 1 y would eliminate any disparities in circulating concentrations of 25(OH)D between African American and white men. %26lt;br%26gt;Design: Serum concentrations of 25(OH)D were measured every 2 mo in 47 subjects who received a daily oral dose of 4000 IU vitamin D3 for I y. %26lt;br%26gt;Results: More than 90% of African Americans had serum concentrations of 25(OH)D %26lt;32 ng/mL, and approximately two-thirds had serum concentrations %26lt;20 ng/mL. Furthermore, there were significant disparities in serum concentrations of 25(OH)D between African American and white men. Supplementation with 4000 IU/d for 1 y eliminated any significant differences in circulating concentrations of 25(OH)D between African American and white men. %26lt;br%26gt;Conclusion: The results of this clinical study show the feasibility and efficacy of this approach in the elimination of hypovitaminosis D, which is a widespread health disparity among African Americans. This trial was registered at clinicaltrials.gov as NCT01045109. Am J Clin Num 2012:96:332-6.

• 出版日期2012-8