Aspirin Use After Diagnosis Improves Survival in Older Adults with Colon Cancer: A Retrospective Cohort Study

作者：Reimers Marlies S; Bastiaannet Esther; van Herk Sukel Myrthe P P; Lemmens Valery E P; van den Broek Colette B M; van de Velde Cornelis J H; de Craen Anton J M; Liefers Gerrit Jan^*

来源：Journal of the American Geriatrics Society, 2012, 60(12): 2232-2236.

DOI：10.1111/jgs.12033

• colon cancer
• aspirin
• survival
• elderly

Objectives To assess survival in relation to aspirin use after diagnosis in older adults with colon cancer. %26lt;br%26gt;Design Subgroup analysis of a previously published cohort and retrospective study. %26lt;br%26gt;Setting Individuals registered in the Eindhoven Cancer Registry (ECR) between 1998 and 2007, linked to prescriptions of low-dose aspirin (80 mg) registered in a community pharmacy database. %26lt;br%26gt;Participants Five hundred thirty-six individuals aged 70 and older diagnosed with colon cancer with or without aspirin use after diagnosis. %26lt;br%26gt;Measurements Survival was analyzed with user status as a time-dependent covariate. Multivariate Poisson regression survival models were used to study the effect of aspirin on overall survival. %26lt;br%26gt;Results One hundred seven participants (20.0%) started aspirin after being diagnosed with colon cancer; 429 (80.0%) were not prescribed aspirin. Three hundred thirty-nine participants (63.2%) had died by the end of follow-up. Aspirin use after diagnosis was associated with longer overall survival (rate ratio (RR) = 0.51, 95% confidence interval (CI) = 0.380.70, P %26lt; .001). Multivariate proportional hazards regression analysis revealed that aspirin use was associated with longer overall survival (adjusted RR = 0.59, 95% CI = 0.440.81, P = .001). %26lt;br%26gt;Conclusion Aspirin use after the diagnosis of colon cancer in older adults was associated with longer survival. Low-dose aspirin could be used as an effective adjuvant therapy in older adults with colon cancer. J Am Geriatr Soc 60:2232-2236, 2012.

• 出版日期2012-12