Diffusion Kurtosis Imaging of Acute Infarction: Comparison with Routine Diffusion and Follow-up MR Imaging

作者：Yin, Jianzhong; Sun, Haizhen; Wang, Zhiyun; Ni, Hongyan; Shen, Wen; Sun, Phillip Zhe^*

来源：Radiology, 2018, 287(2): 651-657.

DOI：10.1148/radiol.2017170553

• ACUTE STROKE
• ISCHEMIC-STROKE
• TISSUE ACIDIFICATION
• ENDOVASCULAR THERAPY
• DWI MISMATCH
• ANIMAL-MODEL
• PERFUSION
• TIME
• LESION
• RECANALIZATION

Purpose: To determine the relationship between diffusion-weighted imaging (DWI) and diffusion kurtosis imaging (DKI) in patients with acute stroke at admission and the tissue outcome 1 month after onset of stroke. @@@ Materials and Methods: Patients with stroke underwent DWI (b values = 0, 1000 sec/mm(2) along three directions) and DKI (b values = 0, 1000, 2000 sec/mm(2) along 20 directions) within 24 hours after symptom onset and 1 month after symptom onset. For large lesions (diameter >= 1 cm), acute lesion volumes at DWI and DKI were compared with those at follow-up T2-weighted imaging by using Spearman correlation analysis. For small lesions (diameter < 1 cm), the number of acute lesions at DWI and DKI and follow-up T2-weighted imaging was counted and compared by using the McNemar test. @@@ Results: Thirty-seven patients (mean age, 58 years; range, 35-82 years) were included. There were 32 large lesions and 138 small lesions. For large lesions, the volumes of acute lesions on kurtosis maps showed no difference from those on 1-month follow-up T2-weighted images (P = .532), with a higher correlation coefficient than those on the apparent diffusion coefficient and mean diffusivity maps (R-2 = 0.730 vs 0.479 and 0.429). For small lesions, the number of acute lesions on DKI, but not on DWI, images was consistent with that on the follow-up T2-weighted images (P = .125). @@@ Conclusion: DKI complements DWI for improved prediction of outcome of acute ischemic stroke.

• 出版日期2018-5
• 单位天津市第一中心医院; 天津医科大学