A new route to 1,4-oxazepanes and 1,4-diazepanes from Garner aldehyde

作者：Das Sanjit Kumar; Srivastava Ajay Kumar; Panda Gautam^*

来源：Tetrahedron Letters, 2010, 51(11): 1483-1485.

DOI：10.1016/j.tetlet.2010.01.035

A highly efficient and convenient method for the synthesis of substituted chiral 1,4-oxazepanes and 1,4-diazepanes have been described from Garner aldehyde through reductive amination with amino ester hydrochlorides followed by intramolecular cyclization as the key steps.

• 出版日期2010-3-17