Alterations of the blood-brain barrier in cerebral white in the ageing brain

作者：Simpson Julie E; Wharton Stephen B; Cooper James; Gelsthorpe Catherine; Baxter Lynne; Forster Gillian; Shaw Pamela J; Savva George; Matthews Fiona E; Brayne Carol; Ince Paul G^*

来源：Neuroscience Letters, 2010, 486(3): 246-251.

DOI：10.1016/j.neulet.2010.09.063

• White matter lesions
• Blood-brain barrier
• Tight junction proteins
• Claudin 5
• Occludin
• ZO 1

White matter lesions (WML) are associated with dementia and are common in brain ageing In order to determine whether alteration of the blood-brain barrier (BBB) may contribute to the pathogenesis of WML we assessed albumin leakage and expression of the tight Junction (TJ) proteins claudin-5 (Cln-5) zona occludin-1 (ZO-1) and occludin in cases derived from the Medical Research Council Cognitive Function and Ageing Study Albumin extravasation was widespread in the ageing brain and enhanced in WML, suggesting dysfunction of the BBB may contribute to the pathogenesis of WML This was not accompanied by significant changes in the endothelial expression of TJ proteins However ZO-1 and occludin were expr

• 出版日期2010-12-17