科研之友
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摘要
Advanced Colorectal Cancer - State of the Art 2011
Palliative treatment of advanced colorectal cancer aims at prolonging overall survival, alleviating symptoms and improving patient's quality of life. The development of new monoclonal antibodies and more effective chemotherapeutics has effectively improved the patient's prognosis, raising median survival to more than 2 years. Treatment decisions strongly depend upon the patient's individual clinical status: surgical resection of liver metastases, if possible, is the primary goal; otherwise, potentially resectable metastases should be downsized and thus converted into a resectable and maybe curative disease. Such a combination therapy is also indicated when tumor-associated symptoms, cancer-associated complications or rapid disease progression occur. Another aspect of new treatment strategies is the de-escalation of therapy with the initiation of maintenance therapies or even drug holidays to decrease toxicity and to improve quality of life. This strategy is called continuum of care approach and has replaced the classic treatment according to treatment lines. Lastly, modern therapy is integrating molecular markers such as the mutational status of KRAS into treatment decisions, thereby further personalizing cancer care in patients with colorectal carcinoma.
- 出版日期2011
