A Porcine Model of Familial Adenomatous Polyposis

作者：Flisikowska Tatiana; Merkl Claudia; Landmann Martina; Eser Stefan; Rezaei Nousin; Cui Xinxin; Kurome Mayuko; Zakhartchenko Valeri; Kessler Barbara; Wieland Hagen; Rottmann Oswald; Schmid Roland M; Schneider Guenter; Kind Alexander; Wolf Eckhard; Saur Dieter; Schnieke Angelika^*

来源：Gastroenterology, 2012, 143(5): 1173-+.

DOI：10.1053/j.gastro.2012.07.110

• Colon Cancer
• Model System
• Tumor Development
• Genetic Predisposition

We created gene-targeted pigs with mutations in the adenomatous polyposis coli (APC) gene (APC) that are orthologous to those responsible for human familial adenomatous polyposis (FAP). One-year-old pigs with the APC(1311) mutation (orthologous to human APC(1309)) have aberrant crypt foci and low-and high-grade dysplastic adenomas in the large intestine, similar to the precancerous lesions that develop in patients with FAP. Dysplastic adenomas accumulate beta-catenin and lose heterozygosity of APC. This large-animal, genetic model of FAP will be useful in the development of diagnostics and therapeutics for colorectal cancer. DNA sequence data: NCBI accession number GU951771.

• 出版日期2012-11