Assessment of rosacea severity: A review of evaluation methods used in clinical trials

作者：Hopkinson Dennis; Tuchayi Sara Moradi; Alinia Hossein^*; Feldman Steven R

来源：Journal of the American Academy of Dermatology, 2015, 73(1): 138-U224.

DOI：10.1016/j.jaad.2015.02.1121

• erythema
• ocular rosacea
• papules and pustules
• phymatous rosacea
• rosacea
• scale self-assessment
• severity
• telangiectasias
• treatment

Background: Novel rosacea treatments are needed. Assessment methodologies for clinical trials of rosacea treatments are not standardized and are relatively inadequate. To determine the efficacy of new treatments, a valid and reliable assessment methodology is needed.
Objective: We sought to determine the assessment methodologies used in clinical trials for rosacea treatments, to demonstrate the need for a valid and reliable assessment tool, and to describe the relevant properties of such a tool.
Methods: PubMed and MEDLINE were searched for clinical trials of rosacea treatments since January 1, 1985.
Results: In all, 32 clinical trials met inclusion criteria. Assessment methodologies were highly variable, and standardized assessment methodologies were used in only 3 studies. The various manifestations of rosacea were assessed inconsistently.
Limitations: Eighteen articles could not be included as a result of lack of access to the full text.
Conclusions: The diverse methodologies make the assessment of novel treatments and comparison of treatments difficult. A valid and reliable assessment tool is needed to properly assess novel treatments to improve the management of rosacea.

• 出版日期2015-7