Does the Addition of Recombinant Luteinizing Hormone to Progesterone for Luteal Supplementation Improve IVF Outcomes in High-Responder Patients? A Preliminary Randomized Controlled Study

作者：Seckin Berna^*; Ozaksit Gulnur; Oruc Ayla Sargin; Yilmaz Nafiye

来源：Journal of Reproductive Medicine, 2014, 59(5-6): 321-326.

• fertility techniques
• in vitro fertilization
• infertility
• luteal phase support
• recombinant luteinizing hormone
• vaginal progesterone

OBJECTIVE: To determine the impact of recombinant luteinizing hormone (rLH) combined with vaginal progesterone (P) for luteal supplementation on in vitro fertilization (IVF) pregnancy outcomes in high-responder patients undergoing long gonadotropin-releasing hormone (GnRH) agonist cycles.
STUDY DESIGN: A total of 47 patients undergoing IVF cycles with the serum estradiol levels of 2,500 pg/mL on the day of human chorionic gonadotropin administration were included in this prospective randomized study. Patients were divided into 2 treatment groups: the control group (n=23) used luteal vaginal P. and the study group (n=24) received a combination of vaginal P and 75 IU rLH, 4 doses every 3 days, starting on the day of embryo transfer. The main outcome measure was the. clinical pregnancy rate (PR).
RESULTS: The study group had 11 pregnancies (45.8%), while the control group had 6 (26.1%). There was no significant difference between the groups in clinical PRs (p = 0.15). No differences were found with respect to the implantation rate, miscarriage rate, and multiple PR.
CONCLUSION: Our data show that luteal supplementation with rLH combined to vaginal P was not found to improve pregnancy outcomes in high responder patients undergoing long GnRH agonist IVF treatments.

• 出版日期2014-6