Morphology Regulatory Metabolites from Arthrobotrys oligospora

作者:Zhang, Hui-Xiang; Tan, Jian-Lin; Wei, Lu-Xia; Wang, Yan-Li; Zhang, Chuan-Ping; Wu, De-Kai; Zhu, Chun-Yan; Zhang, Ying; Zhang, Ke-Qin*; Niu, Xue-Mei
来源:Journal of Natural Products, 2012, 75(7): 1419-1423.
DOI:10.1021/np300342w

摘要

Novel autoregulatory metabolites, arthrosporols A-C (1-3), involved in regulating the morphological switch in fungi, were purified and characterized from the carnivorous fungus Arthrobotrys oligospora. These compounds possess a novel hybrid carbon skeleton consisting of an epoxy-cyclohexenol combined with a rare monocyclic sesquiterpenol substructure. This is the first report of a monocyclic sesquiterpenol of this type of fungal origin. Compounds 1-3 displayed significant inhibitory activities toward the formation of conidiophores, while compounds 1 and 3 showed the opposite effects on the formation of a two-dimensional network with increasing rates of 40-90% and inhibiting rates of 30-90%, respectively.