Drug Synthesis and Analysis on a Dime: A Capstone Medicinal Chemistry Experience for the Undergraduate Biochemistry Laboratory

作者：Streu Craig N; Reif Randall D; Neiles Kelly Y; Schech Amanda J; Mertz Pamela S^*

来源：Journal of Chemical Education, 2016, 93(12): 2084-2088.

DOI：10.1021/acs.jchemed.6b00048

• Upper-Division Undergraduate
• Biochemistry
• Organic Chemistry
• Interdisciplinary/Multidisciplinary
• Laboratory Instruction
• Inquiry-Based/Discovery Learning
• Medicinal Chemistry
• Enzymes

Integrative, research-based experiences have shown tremendous potential as effective pedagogical approaches. Pharmaceutical development is an exciting field that draws heavily on organic chemistry and biochemistry techniques. A capstone drug synthesis/analysis laboratory is described where biochemistry students synthesize azo-stilbenoid compounds and test the biological activity of those compounds as well as a known inhibitor on mushroom tyrosinase using UV/vis-based kinetic assays. In this paper, three such successful azo-stilbenoid inhibitors of tyrosinase, representative student generated data, technical aspects of the experiments, and an interpretation of student feedback on the project as a whole are presented.

• 出版日期2016-12