Apolipoprotein B gene polymorphisms in patients from Serbia with ischemic cerebrovascular disease

作者：Stankovic Aleksandra^*; Stankovic Sanja; Jovanovic Markovic Zagorka; Zivkovic Maja; Djuric Tamara; Glisic Milosavljevic Sanja; Alavantic D

来源：Archives of Biological Sciences, 2007, 59(4): 303-309.

DOI：10.2298/ABS0704303S

• ApoB
• ischemic cerebrovascular disease
• gene
• polymorphism
• human population
• Serbia

The plasma concentration of apoB has recently been reported to be the best lipid predictor of coronary heart disease. The possible associations of genetic markers in the apolipoprotein B gene (Xbal, EcoRI, MspI, Ins/Del, and 4311 A/G polymorphisms) were evaluated in patients with ischemic cerebrovascular disease (ICVD) and controls of equivalent BMI. The odds ratio for ICVD in the X+X+ genotype was 2.22, 95% CI 1.24-3.96 (P<0.05), while that for ICVD in the Ins/Ins genotype was 2.82, 95% CI 1.57-5.06 (P<0.05). The patients had significantly higher frequency of the 4311 A allele compared to the controls (P<0.01). Our results support the assumption that apoB gene polymorphisms may contribute to the extent of cerebrovascular disease risk.

• 出版日期2007
• 单位河北医科大学