High levels of anti-tuberculin (IgG) antibodies correlate with the blocking of T-cell proliferation in individuals with high exposure to Mycobacterium tuberculosis

作者：Feris Edmond J; Encinales Liliana; Awad Carlos; Stern Joel N H; Tabansky Inna; Jimenez Alvarez Luis; Ramirez Martinez Gustavo; Cruz Lagunas Alfredo; Bobadilla Karen; Marquez Eduardo; Granados Montiel Julio; Rodriguez Reyna Tatiana S; Fernandez Vina Marcelo; Granados Julio; Zuniga Joaquin; Yunis Edmond J^*

来源：International Journal of Infectious Diseases, 2016, 43: 21-24.

DOI：10.1016/j.ijid.2015.12.004

• Tuberculosis
• Mycobacterium tuberculosis
• Latent tuberculosis
• Humoral immunity
• Anti-tuberculin antibodies
• T-cell proliferation

Objectives: To determine the effect of anti-tuberculin antibodies in the T-cell proliferation in response to tuberculin and Candida antigens in individuals with different levels of tuberculosis (TB) risk.
Methods: Sixteen high-risk TB individuals, 30 with an intermediate TB risk (group A), and 45 with a low TB risk (group B), as well as 49 control individuals, were studied. Tuberculin skin test (TST) results were analyzed and serum levels of antibodies (IgG and IgM) against purified protein derivative (PPD) were measured by ELISA. Tuberculin and Candida antigens were used to stimulate T-cell proliferation in the presence of human AB serum or autologous serum.
Results: High levels of anti-tuberculin IgG antibodies were found to be significantly associated with the blocking of T-cell proliferation responses in cultures stimulated with tuberculin but not with Candida antigens in the presence of autologous serum. This phenomenon was particularly frequent in high-risk individuals with high levels of anti-tuberculin IgG antibodies in the autologous serum when compared to the other risk groups, which exhibited lower levels of anti-tuberculin antibodies.
Conclusions: Although cellular immunity plays a central role in the protection against TB, humoral immunity is critical in the control of Mycobacterium tuberculosis infection in high-risk individuals with latent TB infection.

• 出版日期2016-2
• 单位河北医科大学