Design of an in-dwelling cannula for convection-enhanced delivery

作者：Rosenbluth Kathryn H; Luz Matthias; Mohr Erich; Mittermeyer Stephan; Bringas John; Bankiewicz Krystof S^*

来源：Journal of Neuroscience Methods, 2011, 196(1): 118-123.

DOI：10.1016/j.jneumeth.2010.12.022

• Convection-enhanced delivery
• Cannula
• Infusion
• MRI
• Non-human primate
• Neuro-oncology
• Neurodegeneration

Failures of recent convection-enhanced delivery (CEO) trials have underscored the need for improved CED cannulae. This study presents a novel in-dwelling cannula targeted for use in upcoming neurooncological or neurodegeneration trials. The cannula is reflux-resistant and easily integrated into clinical workflows. The cannula was evaluated in non-human primate CED studies performed with magnetic resonance imaging (MRI) to validate the effectiveness and safety of the infusion.

• 出版日期2011-3-15