Nickel-Catalyzed Synthesis of Stereochemically Defined Enamides via Bi- and Tricomponent Coupling Reaction

作者：Liu Y; De Nisi A; Cerveri A; Monari M; Bandini M^*

来源：Organic Letters, 2017, 19(19): 5034-5037.

DOI：10.1021/acs.orglett.7b02166

The stereoseleetive synthesis of (E)-trisubstituted tertiary enamides is documented via site-selective Ni-catalyzed beta-arylation of allenamides with boronic acids in high yields (up to 89%). The nucleophilic character of the "organo-Ni" intermediates is further exploited to implement a one-pot tricomponent procedure involving the final allylation of aldehydes (yields up to 93%). Mechanistic insights and efficiency on a gram scale process were also documented.

• 出版日期2017-10-6