Distribution of Fatty Acids in Adipose Tissue of Patients with Type 2 Diabetes

作者：Korani Mohsen; Firoozrai Mohsen; Maleki Jafar; Ghahramanpour Faranak; Heidari Iraj; Fallah Soudabeh^*; Seifi Morteza

来源：Clinical Laboratory, 2012, 58(5-6): 457-464.

• Adipose tissue
• palmitic acid
• polyunsaturated fatty acids
• type 2 diabetes

Background: It is not known whether alterations of adipose tissue fatty acid compositions predict type 2 diabetes. Our goal was to characterize the relationship between the adipose tissue fatty acid compositions and type 2 diabetes. %26lt;br%26gt;Methods: We evaluated the fatty acid compositions of subcutaneous adipose tissue. These analyses were carried out on samples from 76 normal and 98 diabetic adults. Analysis was performed on a gas chromatograph. %26lt;br%26gt;Results: The adipose tissue palmitic acid composition of diabetic subjects (24.9% +/- 0.3) was significantly higher (p = 0.01) than in the controls (23.3% +/- 1.6). A significant negative correlation (r = -0.276, p = 0.001) was found between adipose tissue polyunsaturated fatty acids (PUFAs) and the Chol/HDL-C ratio of all the subjects studied (controls plus diabetic patients). A similar negative correlation (r = -0.429, p = 0.001) was identified only for control group, whereas no significant correlation (p%26gt;0.05) was found for diabetic populations. The correlation between fatty acid compositions and serum lipid profiles (TG, HDL-C, Chol/HDL-C, LDL-C/HDL-C proportion) and fasting blood sugar (FBS) with HbA1c concentrations of people with diabetes and controls was not significant. %26lt;br%26gt;Conclusions: A high amount of palmitic acid in adipose tissue may increase the risk of the type 2 diabetes and it seems that a high intake of PUFAs can lead to lowering of the Chol/HDL-C ratio. (Clin. Lab. 2012;58:457-464)

• 出版日期2012