A study of association between expression of hOGG1, VDAC1, HK-2 and cervical carcinoma

作者：Peng Guo-Qing; Yang Yuan^*; Zhong Cai-Gao; Yin Hongling; Hu Gonghua; Tian Yan

来源：Journal of Experimental & Clinical Cancer Research, 2010, 29: 129.

DOI：10.1186/1756-9966-29-129

• MITOCHONDRIAL BINDING
• DNA GLYCOSYLASE
• HEXOKINASE-II
• RISK-FACTORS
• CANCER
• GLYCOLYSIS
• P16(INK4A)
• NEOPLASIA
• APOPTOSIS
• CLONING

Background: Human 8-oguanine glycosylase 1(hOGG1), voltage-dependent anion channel 1(VDAC1), hexokinase 2 (HK-2), represented the process of oxidative DNA damage, cell apoptosis and glycolysis, respectively. This study aims to explore the association between expression of hOGG1, VDAC1, HK-2 and cervical carcinoma.
Methods: A case-control study was conducted. 65 cervical biopsy samples consist of 20 control and 45 cases. The expression of hOGG1, VDAC1 and HK-2 were examined with immunohistochemistry(IHC), immunolabeling was evaluated with stereological cell counts.
Results: The data showed that the positive proportion of hOGG1 and HK-2 in the case group was higher than that of the control group (P < 0.05). Further, there was an increasing trend for the positive proportion and expression degree of hOGG1 and HK-2 from Control, Mild cervical carcinoma (MCC), Intermediate cervical carcinoma(ICC) to Severe cervical carcinoma(SCC) in order (P < 0.05). To VDAC1, the significant result was not obtained.
Conclusions: The results suggested that there was a close association between expression of hOGG1, HK-2 and cervical cancer. hOGG1 and HK-2 might play a key role at the early stage of cervical cancer, and the findings of hOGG1 and HK-2 should be considered as a significant biomarker at the early stage of cervical cancer.

• 出版日期2010-9-17
• 单位湖南医药学院