A numerical model of a red blood cell infected by Plasmodium falciparum malaria: coupling cell mechanics with ligand-receptor interactions

作者：Ishida Shunichi; Imai Yohsuke^*; Ichikawa Yuki; Nix Stephanie; Matsunaga Daiki; Omori Toshihiro; Ishikawa Takuji

来源：Science and Technology of Advanced Materials, 2016, 17(1): 454-461.

DOI：10.1080/14686996.2016.1211462

• Nanomedicine molecular science
• computational biomechanics
• malaria
• cell adhesion

We developed a numerical model of the behavior of a red blood cell infected by Plasmodium falciparum malaria on a wall in shear flow. The fluid and solid mechanics of an infected red blood cell (Pf-IRBC) were coupled with the biochemical interaction of ligand-receptor bindings. We used the boundary element method for fluid mechanics, the finite element method for membrane mechanics, and the Monte Carlo method for ligand-receptor interactions. We simulated the behavior of a Pf-IRBC in shear flow, focusing on the effects of bond type. For slip bonds, the Pf-IRBC exhibited firm adhesion, tumbling motion, and tank-treading motion, depending on the applied shear rate. The behavior of catch bonds resembled that of slip bonds, except for a 'catch' state at high shear stress. When the reactive compliance decreased to a value in the order of 10(-2) nm, both the slip and catch bonds behaved like an ideal bond. Such bonds do not respond to the force applied to the bond, and the velocity is stabilized at a high shear rate. Finally, we compared the numerical results with previous experiments for A4- and ItG-infected cells. We found that the interaction between PfEMP1 and ICAM-1 could be a nearly ideal bond, with a dissociation rate ranging from 30 s(-1) to 100 s(-1).
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• 出版日期2016