Antiphospholipid antibody syndrome and reproduction

作者：Kutteh William H^*

来源：Current Opinion in Obstetrics and Gynecology, 2014, 26(4): 260-265.

DOI：10.1097/GCO.0000000000000086

• antiphospholipid antibodies
• antiphospholipid antibody syndrome
• heparin
• recurrent pregnancy loss

Purpose of review
To review the recent diagnostic criteria, clinical implications, and therapeutic protocols for antiphospholipid antibody syndrome (APS).
Recent findings
Much has been learned in the recent years concerning the diagnosis of and clinical implications associated with the APS. A number of studies demonstrate some pathophysiologic mechanisms that suggest the impact of antiphospholipid antibodies (APAs) on successful growth and development of the placenta, and ultimately the embryo. These findings are discussed in context with establishing the Bradford Hill criteria for causation between APAs and recurrent pregnancy loss. The recent clinical recommendations from the American Society for Reproductive Medicine and the American College of Obstetrics and Gynecology are included. Practical guidelines for clinicians faced with treating women with antiphospholipid syndrome are presented.
Summary
The diagnosis of APS is defined and the clinical treatment protocol recommendations are discussed.

• 出版日期2014-8