Different prognostic value of white blood cell subtypes in patients with acute cerebral infarction

作者：Kim Jinkwon; Song Tae Jin; Park Ji Hye; Lee Hye Sun; Nam Chung Mo; Nam Hyo Suk; Kim Young Dae; Heo Ji Hoe^*

来源：Atherosclerosis, 2012, 222(2): 464-467.

DOI：10.1016/j.atherosclerosis.2012.02.042

• Leukocyte
• White blood cell
• Lymphocyte
• Stroke

Objective: We aimed to investigate the relationship of each white blood cells (WBC) subtype with neurologic severity and outcome in acute stroke.
Methods: We included 779 patients with first-ever acute cerebral infarction within 72 h after symptom onset. We investigated the association between counts for WBC subtypes in peripheral blood at admission and (1) initial stroke severity; (2) early change in stroke severity within one week; and (3) functional outcome at three months.
Results: Higher total WBC and neutrophil counts were associated with more severe stroke at admission (p < 0.001). In contrast, lower lymphocyte counts were associated with a lesser improvement during the first week after admission (p < 0.05) and with poor functional outcome at three months (OR = 0.706 per 1000 lymphocyte counts/mm(3), p = 0.020).
Conclusions: Our study merits further investigation on the role of each WBC subtype in ischemic injury and different prognostic value of WBC subtypes measured at admission in acute stroke.

• 出版日期2012-6