Association of KIBRA rs17070145 polymorphism and episodic memory in individuals with severe TBI

作者：Wagner Amy K^*; Hatz Laura E; Scanlon Joelle M; Niyonkuru Christian; Miller Megan A; Ricker Joseph H; Conley Yvette P; Ferrell Robert E

来源：Brain Injury, 2012, 26(13-14): 1658-1669.

DOI：10.3109/02699052.2012.700089

• Traumatic brain injury
• cognition
• memory
• KIBRA
• genetic polymorphism

Background: Studies implicate single nucleotide polymorphism (SNP) rs17070145, a common T --> C polymorphism on the KIBRA gene, in mediating differences in episodic memory. In healthy adults, T-allele carriers perform better than non-carriers on episodic memory measures. However, this association is reversed in adults with subjective memory complaints and populations vulnerable to memory deficits, a problem common in traumatic brain injury (TBI).
Methods: This study assessed associations between variation in the KIBRA gene and cognitive function in 129 adults with severe TBI. In addition to other executive functioning and functional/global outcomes, the Buschke Selective Reminding Test (SRT), Rey-Osterrieth Complex Figure Test and California Verbal Learning Test-II (CVLT-II) were administered 6 and 12 months post-injury.
Results: T-allele non-carriers performed better than carriers on multiple episodic memory measures. At 6 months, T-allele non-carriers performed better for delayed recall measures on the SRT. At 12 months, T-allele non-carriers performed better on multiple SRT measures and on List-B learning with CVLT-II. No associations occurred with executive function or global outcome measures.
Conclusion: These results suggest that rs17070145 T-allele effects are specific to episodic memory and support the hypothesis that associations between rs17070145 variation and memory are disparate between healthy and impaired populations.

• 出版日期2012-12