Autophagy-mediated antigen processing in CD4(+) T cell tolerance and immunity

作者：Klein Ludger^*; Muenz Christian; Luenemann Jan D

来源：FEBS Letters, 2010, 584(7): 1405-1410.

DOI：10.1016/j.febslet.2010.01.008

• Antigen presentation
• T cell selection
• Innate immunity
• Macroautophagy
• Intracellular pathogen
• Vaccination

Macroautophagy, a homeostatic process that shuttles cytoplasmic constituents into endosomal and lysosomal compartments, has recently been shown to deliver antigens for presentation on major histocompatibility complex (MHC) class II. Autophagy-mediated antigen processing in thymic epithelial cells has been suggested to be involved in the generation of a self-MHC restricted and self-tolerant CD4(+) T cell repertoire. Furthermore, there is accumulating evidence that the up-regulation of autophagy by pattern-recognition receptor signaling represents an innate defense mechanism against intracellular pathogens. Thus, through linking pathogen breakdown with the presentation of pathogen-derived autophagy substrates on MHC class II, autophagy serves a dual function at the interface of the innate and the adaptive immune response.

• 出版日期2010-4-2