A convenient procedure for N-formylation of amines

作者：Joseph Sony; Das Prasenjit; Srivastava Bindu; Nizar Hashim^*; Prasad Mohan

来源：Tetrahedron Letters, 2013, 54(8): 929-931.

DOI：10.1016/j.tetlet.2012.12.009

• N-formylation
• Amines
• Amino acids
• Amino esters
• Formamide
• Sodium methoxide
• Amidation

A simple and convenient method for the N-formylation of primary and secondary amines including amino acids has been developed utilizing formamide and sodium methoxide in moderate to excellent yield. This reagent is also utilized for one pot conversion of compounds having amino esters to N-formyl amides.

• 出版日期2013-2