AN ENANTIO- AND DIASTEREOCONTROLLED SYNTHESIS OF (-)-SALINOSPORAMIDE A

作者：Sato Yosuke^*; Fukuda Hayato; Tomizawa Masaki; Masaki Tomohito; Shibuya Masatoshi; Kanoh Naoki; Iwabuchi Yoshiharu

来源：Heterocycles, 2010, 81(10): 2239-2246.

DOI：10.3987/COM-10-12042

• Salinosporamide A
• Total Synthesis
• Reformatsky Reaction
• Rh-Catalysis
• AZADO

The enantio- and diastereocontrolled total synthesis of (-)-salinosporamide A, a potent 20S proteasome inhibitor, was accomplished through organocatalytic aldolization, diastereoselective Claisen condensation, a Rh-catalyzed Reformatsky reaction, and an AZADO-catalyzed oxidative beta-lactonization reaction as the key reactions.

• 出版日期2010-10-1