Design of task-specific ionic liquid, 1-(ethylaceto acetate)-1-(2-hydroxyethyl) piperidinium tetrachloroaluminate for multicomponent synthesis of 3,3 '-disubstituted oxindoles

Dige Nilam C; Korade Suyog N; Pore Dattaprasad M<sup>*</sup>

doi:10.1007/s11164-017-3034-0

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Design of task-specific ionic liquid, 1-(ethylaceto acetate)-1-(2-hydroxyethyl) piperidinium tetrachloroaluminate for multicomponent synthesis of 3,3 '-disubstituted oxindoles

作者：Dige Nilam C; Korade Suyog N; Pore Dattaprasad M^*

来源：Research on Chemical Intermediates, 2017, 43(12): 7029-7040.

DOI：10.1007/s11164-017-3034-0

摘要

We have designed and synthesized an efficient novel task-specific ionic liquid, 1-(ethylaceto acetate)-1-(2-hydroxyethyl) piperidinium tetrachloroaluminate [EAHEPiPY](+) [AlCl4](-). Its catalytic efficiency was explored for multicomponent reaction of isatin(s), malononitrile, and indole(s) furnished corresponding 3,3'-disubstituted oxindoles via tandem Knoevenagel/Michael addition reaction in excellent yield at 80 degrees C in mixed solvent system, water: ethanol (80:20%). [GRAPHICS] .