Asymmetric Transfer Hydrogenation of Aromatic Ketones Catalyzed by New Chiral C2-Symmetric Bis(sulfonyl) tetraaza Ligands Complexed with [Ru(eta (6)-p-cymene)Cl-2](2) in Water

作者：Liu, Xungao; Zhang, Tian; Hu, Yingying; Shen, Liang^*

来源：Catalysis Letters, 2014, 144(7): 1289-1295.

DOI：10.1007/s10562-014-1254-0

• Bis(sulfonyl) tetraaza
• Asymmetric transfer hydrogenation
• Ruthenium
• Ketones
• HCOONa

In this report, a new series of C2-symmetric bis(sulfonyl) tetraaza ligands were synthesized from (1S,2S)-1,2-diarylethylenediamine analogues and tested in the asymmetric transfer hydrogenation (ATH) of aromatic ketones by complexing with [Ru(eta (6)-p-cymene)Cl-2](2) employing sodium formate as hydrogen source in neat water. A moderate to excellent conversion (similar to 99.8 %) and overall satisfying enantioselectivity (similar to 92.8 %) were obtained with varied electronic and steric effects of the substituents on ligands and substrates.
A new series of C2-symmetric bis(sulfonyl) tetraaza ligands was synthesized from (1S,2S)-1,2-diarylethylenediamine analogues and tested in the asymmetric transfer hydrogenation of aromatic ketones by complexing with [Ru(eta(6)-p-cymene)Cl-2](2) employing formate sodium as hydrogen source in neat water. A moderate to excellent conversion (similar to 99.8 %) and overall satisfying enantioselectivity (similar to 92.8 %) were obtained with varied electronic and steric effects of the substituents on ligands and substrates.

• 出版日期2014-7
• 单位杭州师范大学