Antibacterial activity of aminoderivatized chitosans against methicillin-resistant Staphylococcus aureus (MRSA)

作者：Lee Dae Sung; Jeong Seong Yun; Kim Young Mog; Lee Myung Suk; Ahn Chang Bum; Je Jae Young^*

来源：Bioorganic & Medicinal Chemistry, 2009, 17(20): 7108-7112.

DOI：10.1016/j.bmc.2009.09.007

• MRSA
• Antimicrobial agent
• Aminoderivatized chitosans

This work describes the anti-MRSA activity of aminoderivatized chitosans. Two kinds of aminoethylchitosans (AEC), AEC90 and AEC50, having degrees of deacetylation of 90% and 50%, respectively, exhibited the strongest anti-MRSA activities by presenting MICs of 16-64 mu g/mL against two standard strains and twelve clinical isolates. The bactericidal activity, thermal and pH stability, and cell membrane integrity effects of AEC90 and AEC50 are also discussed.

• 出版日期2009-10-15