New steroidal saponins with cytotoxic activities from Smilax trinervula

作者:Liang, Fang; He, Jun-Wei; Zhu, Gen-Hua; Liu, Rong-Hua; Shu, Ji-Cheng; Shao, Feng; Huang, Hui-Lian*
来源:Phytochemistry Letters, 2016, 16: 294-298.
DOI:10.1016/j.phytol.2016.05.011

摘要

Three new steroidal saponins, namely, trinervulosides A-C (1-3), were isolated from the rhizomes and roots of Smilax trinervula, together with four known compounds, 4-7. Their structures were determined through chemical evidence, NMR spectroscopy, mass spectrometry and comparison with the literature. Compounds 1-7 were assayed for cytotoxic activities, and only trinervuloside B (2) showed activity against SGC-7901 and HCT-116 cell lines.