Blood to skin recirculation of CD4(+) memory T cells associates with cutaneous and systemic manifestations of psoriatic disease

作者：Diani Marco; Galasso Marco; Cozzi Chiara; Sgambelluri Francesco; Altomare Andrea; Cigni Clara; Frigerio Elena; Drago Lorenzo; Volinia Stefano; Granucci Francesca; Altomare Gianfranco; Reali Eva^*

来源：Clinical Immunology, 2017, 180: 84-94.

DOI：10.1016/j.clim.2017.04.001

Blood to skin recirculation could play a role in the pathogenesis of psoriasis. To investigate this possibility we dissected the phenotype of circulating T cells in psoriasis patients, calculated the correlation the clinical parameters of the disease and performed a parallel bioinformatics analysis of gene expression data in psoriatic skin. We found that circulating CCR6(+) CD4(+) TEM and TEFF cells significantly correlated with systemic inflammation. Conversely, the percentage of CXCR3(+) CD4(+) T-EM cells negatively correlated with the severity of the cutaneous disease.
Importantly CLA(+) CD4(+) T-CM cells expressing CCR6(+) or CCR4(+)CXCR3(+) negatively correlated with psoriasis severity suggesting recruitment to the skin compartment. This assumption was reinforced by gene expression data showing marked increase of CCR7 and CIA-encoding gene SELPLG expression in psoriatic skin and strong association of their expression. The data enlightens a role for CD4(+) T cells trafficking between blood and skin in cutaneous and systemic manifestations of psoriasis.

• 出版日期2017-7