A Case Report of Doxycycline-induced Stevens-Johnson Syndrome

作者：Lau Brian; Mutyala Divya; Dhaliwal Deepinder^*

来源：Cornea, 2011, 30(5): 595-597.

DOI：10.1097/ICO.0b013e3181f05773

• Stevens-Johnson syndrome
• doxycycline

Purpose: To report the clinical findings of a case of Stevens-Johnson syndrome (SJS) precipitated by the use of systemic doxycycline.
Methods: Case report.
Results: A 49-year-old man developed SJS with ocular involvement after doxycycline use for respiratory symptoms. The patient developed persistent 2+ conjunctival injection and foreshortening of the conjunctival fornices in both eyes. The right eye had a 3 x 3.4 mm corneal epithelial defect with 50% thinning. The left eye had a 2.6 x 3 mm corneal ulcer with a central perforation and a flat anterior chamber with 360 degrees of iridocorneal touch.
Conclusions: This case illustrates the unusual presentation of SJS induced by doxycycline. The prevalent use of systemic doxycycline in the practice of ophthalmology for eyelid-related and ocular surface disorders coupled with the detrimental long-term sequelae of SJS renders a careful reevaluation for alternatives.

• 出版日期2011-5