An Effective Nitrilimine Cycloaddition for the Synthesis of 1,3,5-Trisubstituted 1,2,4-Triazoles from Oximes with Hydrazonoyl Hydrochlorides

作者：Wang Li Ya; Tseng Wen Che; Lin Hui Yi; Wong Fung Fuh^*

来源：Synlett, 2011, (10): 1467-1471.

DOI：10.1055/s-0030-1260759

• 1,2,4-triazoles
• hydrazonoyl hydrochloride
• nitrilimine
• 1,3-dipolar cycloaddition
• oximes

An effective 1,3-dipolar cycloaddition for the synthesis of 1,3,5-trisubstituted 1,2,4-triazole derivatives was developed by reacting oximes with hydrazonoyl hydrochlorides using triethylamine as a base. The desired 1,3,5-trisubstituted 1,2,4-triazoles were obtained in good yields and the reaction was applicable to aliphatic, cyclic aliphatic, aromatic and heterocyclic oxime substrates.

• 出版日期2011-6
• 单位中国医科大学